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Generalized weakness of limb muscles

MedGen UID:
870172
•Concept ID:
C4024605
•
Finding
Synonym: Generalised weakness of limb muscles
 
HPO: HP:0009028

Definition

Generalized weakness of the muscles of the arms and legs. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Generalized weakness of limb muscles

Professional guidelines

PubMed

Clinical characteristics, treatment and outcome of nivolumab-induced myasthenia gravis.
Wang C, Zeng H, Fang W, Song L
Invest New Drugs 2023 Apr;41(2):333-339. Epub 2023 Mar 29 doi: 10.1007/s10637-023-01347-6. PMID: 36988830
Influence of frailty on treatment outcomes after revascularization in patients with critical limb ischemia.
Morisaki K, Yamaoka T, Iwasa K, Ohmine T
J Vasc Surg 2017 Dec;66(6):1758-1764. Epub 2017 Jun 21 doi: 10.1016/j.jvs.2017.04.048. PMID: 28647199
Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.
Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society, Delgado MR, Hirtz D, Aisen M, Ashwal S, Fehlings DL, McLaughlin J, Morrison LA, Shrader MW, Tilton A, Vargus-Adams J
Neurology 2010 Jan 26;74(4):336-43. doi: 10.1212/WNL.0b013e3181cbcd2f. PMID: 20101040Free PMC Article

Recent clinical studies

Etiology

Virtual reality exercise programs ameliorate frailty and fall risks in older adults: A meta-analysis.
Lee YH, Lin CH, Wu WR, Chiu HY, Huang HC
J Am Geriatr Soc 2023 Sep;71(9):2946-2955. Epub 2023 May 10 doi: 10.1111/jgs.18398. PMID: 37165743
Protein intake and physical function in older adults: A systematic review and meta-analysis.
Coelho-Júnior HJ, Calvani R, Tosato M, Landi F, Picca A, Marzetti E
Ageing Res Rev 2022 Nov;81:101731. Epub 2022 Sep 8 doi: 10.1016/j.arr.2022.101731. PMID: 36087703
Falls and Cancer.
Morris R, Lewis A
Clin Oncol (R Coll Radiol) 2020 Sep;32(9):569-578. Epub 2020 Apr 11 doi: 10.1016/j.clon.2020.03.011. PMID: 32291190
Spinal muscular atrophy.
D'Amico A, Mercuri E, Tiziano FD, Bertini E
Orphanet J Rare Dis 2011 Nov 2;6:71. doi: 10.1186/1750-1172-6-71. PMID: 22047105Free PMC Article
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.
Bensimon G, Lacomblez L, Meininger V
N Engl J Med 1994 Mar 3;330(9):585-91. doi: 10.1056/NEJM199403033300901. PMID: 8302340

Diagnosis

Myasthenia Gravis and Congenital Myasthenic Syndromes.
Ciafaloni E
Continuum (Minneap Minn) 2019 Dec;25(6):1767-1784. doi: 10.1212/CON.0000000000000800. PMID: 31794470
Fasciculating toxicity.
Ranjan A, Jamshed N, Aggarwal P, Upadhyay V
Am J Emerg Med 2019 Apr;37(4):798.e1-798.e2. Epub 2019 Jan 21 doi: 10.1016/j.ajem.2019.01.033. PMID: 30686539
Generalized Myasthenia Gravis: Classification, Clinical Presentation, Natural History, and Epidemiology.
Hehir MK, Silvestri NJ
Neurol Clin 2018 May;36(2):253-260. doi: 10.1016/j.ncl.2018.01.002. PMID: 29655448
Spinal muscular atrophy.
D'Amico A, Mercuri E, Tiziano FD, Bertini E
Orphanet J Rare Dis 2011 Nov 2;6:71. doi: 10.1186/1750-1172-6-71. PMID: 22047105Free PMC Article
Pearls: myasthenia.
Benatar M
Semin Neurol 2010 Feb;30(1):35-7. Epub 2010 Feb 1 doi: 10.1055/s-0029-1244999. PMID: 20127579

Therapy

Virtual reality exercise programs ameliorate frailty and fall risks in older adults: A meta-analysis.
Lee YH, Lin CH, Wu WR, Chiu HY, Huang HC
J Am Geriatr Soc 2023 Sep;71(9):2946-2955. Epub 2023 May 10 doi: 10.1111/jgs.18398. PMID: 37165743
Effects of lower limb resistance exercise on muscle strength, physical fitness, and metabolism in pre-frail elderly patients: a randomized controlled trial.
Lai X, Bo L, Zhu H, Chen B, Wu Z, Du H, Huo X
BMC Geriatr 2021 Jul 30;21(1):447. doi: 10.1186/s12877-021-02386-5. PMID: 34330211Free PMC Article
Myasthenia Gravis and Congenital Myasthenic Syndromes.
Ciafaloni E
Continuum (Minneap Minn) 2019 Dec;25(6):1767-1784. doi: 10.1212/CON.0000000000000800. PMID: 31794470
Myasthenia gravis.
Silvestri NJ, Wolfe GI
Semin Neurol 2012 Jul;32(3):215-26. Epub 2012 Nov 1 doi: 10.1055/s-0032-1329200. PMID: 23117946
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.
Bensimon G, Lacomblez L, Meininger V
N Engl J Med 1994 Mar 3;330(9):585-91. doi: 10.1056/NEJM199403033300901. PMID: 8302340

Prognosis

Clinical characteristics of anti-AChR-MuSK-LRP4 antibody-negative myasthenia gravis in China.
Li W, Liu P, Cui W, Wang S, Ji Y, Zhang L, He X, Zhou S, Shen T, Zhao X, Lv J, Zhang Y, Zhang J, Fang H, Yang J, Zhang Y, Cui X, Zhang Q, Gao F
Muscle Nerve 2023 Jun;67(6):481-488. Epub 2023 Apr 3 doi: 10.1002/mus.27822. PMID: 36945795
Generalized Myasthenia Gravis: Classification, Clinical Presentation, Natural History, and Epidemiology.
Hehir MK, Silvestri NJ
Neurol Clin 2018 May;36(2):253-260. doi: 10.1016/j.ncl.2018.01.002. PMID: 29655448
Spinal muscular atrophy.
D'Amico A, Mercuri E, Tiziano FD, Bertini E
Orphanet J Rare Dis 2011 Nov 2;6:71. doi: 10.1186/1750-1172-6-71. PMID: 22047105Free PMC Article
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II.
Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V
Lancet 1996 May 25;347(9013):1425-31. doi: 10.1016/s0140-6736(96)91680-3. PMID: 8676624
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.
Bensimon G, Lacomblez L, Meininger V
N Engl J Med 1994 Mar 3;330(9):585-91. doi: 10.1056/NEJM199403033300901. PMID: 8302340

Clinical prediction guides

Cardioprotective function of sclerostin by reducing calcium deposition, proliferation, and apoptosis in human vascular smooth muscle cells.
González-Salvatierra S, García-Fontana C, Lacal J, Andújar-Vera F, Martínez-Heredia L, Sanabria-de la Torre R, Ferrer-Millán M, Moratalla-Aranda E, Muñoz-Torres M, García-Fontana B
Cardiovasc Diabetol 2023 Nov 2;22(1):301. doi: 10.1186/s12933-023-02043-8. PMID: 37919715Free PMC Article
Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes.
Shavlakadze T, Xiong K, Mishra S, McEwen C, Gadi A, Wakai M, Salmon H, Stec MJ, Negron N, Ni M, Wei Y, Atwal GS, Bai Y, Glass DJ
Skelet Muscle 2023 Jul 12;13(1):11. doi: 10.1186/s13395-023-00321-3. PMID: 37438807Free PMC Article
Protein intake and physical function in older adults: A systematic review and meta-analysis.
Coelho-Júnior HJ, Calvani R, Tosato M, Landi F, Picca A, Marzetti E
Ageing Res Rev 2022 Nov;81:101731. Epub 2022 Sep 8 doi: 10.1016/j.arr.2022.101731. PMID: 36087703
Clinical and genetic spectrum of a large cohort of patients with δ-sarcoglycan muscular dystrophy.
Alonso-Pérez J, González-Quereda L, Bruno C, Panicucci C, Alavi A, Nafissi S, Nilipour Y, Zanoteli E, Isihi LMA, Melegh B, Hadzsiev K, Muelas N, Vílchez JJ, Dourado ME, Kadem N, Kutluk G, Umair M, Younus M, Pegorano E, Bello L, Crawford TO, Suárez-Calvet X, Töpf A, Guglieri M, Marini-Bettolo C, Gallano P, Straub V, Díaz-Manera J
Brain 2022 Apr 18;145(2):596-606. doi: 10.1093/brain/awab301. PMID: 34515763Free PMC Article
Age-related changes in the structure and function of skeletal muscles.
Faulkner JA, Larkin LM, Claflin DR, Brooks SV
Clin Exp Pharmacol Physiol 2007 Nov;34(11):1091-6. doi: 10.1111/j.1440-1681.2007.04752.x. PMID: 17880359

Recent systematic reviews

A State-of-the-Art of Exoskeletons in Line with the WHO's Vision on Healthy Aging: From Rehabilitation of Intrinsic Capacities to Augmentation of Functional Abilities.
Gavrila Laic RA, Firouzi M, Claeys R, Bautmans I, Swinnen E, Beckwée D
Sensors (Basel) 2024 Mar 30;24(7) doi: 10.3390/s24072230. PMID: 38610440Free PMC Article
The Effects of Combined Exercise with Citrulline Supplementation on Body Composition and Lower Limb Function of Overweight Older Adults: A Systematic Review and Meta-Analysis.
Xie S, Li S, Shaharudin S
J Sports Sci Med 2023 Sep;22(3):541-548. Epub 2023 Sep 1 doi: 10.52082/jssm.2023.541. PMID: 37711701Free PMC Article
Protein intake and physical function in older adults: A systematic review and meta-analysis.
Coelho-Júnior HJ, Calvani R, Tosato M, Landi F, Picca A, Marzetti E
Ageing Res Rev 2022 Nov;81:101731. Epub 2022 Sep 8 doi: 10.1016/j.arr.2022.101731. PMID: 36087703
Health economic evaluation of exercise interventions in people over 60 years old: A systematic review.
Subías-Perié J, Navarrete-Villanueva D, Gómez-Cabello A, Vicente-Rodríguez G, Casajús JA
Exp Gerontol 2022 May;161:111713. Epub 2022 Jan 29 doi: 10.1016/j.exger.2022.111713. PMID: 35104563
Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials.
Mañas A, Gómez-Redondo P, Valenzuela PL, Morales JS, Lucía A, Ara I
Ageing Res Rev 2021 Aug;69:101368. Epub 2021 May 19 doi: 10.1016/j.arr.2021.101368. PMID: 34022464

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